Novel Agarose Bead Production Facility
Purolite Life Sciences’ have invested in a multimillion pound production facility in Wales capable of producing 30% of the world’s agarose demand. The state-of-the-art manufacturing facility designed and built by Briggs of Burton will be located at Purolite’s R&D Centre of Excellence in South Wales. It will be capable of producing 100,000L of high flow agarose resin for their Praesto® range of ion-exchange and Protein A affinity resins, designed for the purification of monoclonal antibodies.
Bespoke Production System
Briggs of Burton supported Purolite in scaling up their process that is capable of handling a range of liquids and powders to produce their product range. Process and Tank Farm/Utility Vessel Package including:
- Wide range of heating and cooling vessels with agitators
- Several mobile vessels fitted with agitators
- A number of wash columns
Integration of Utilities:
- Design and integration of compressed air and nitrogen systems
- Chiller system and purified water system
- Segregated effluent system design to storage tanks
- Bulk chemical and waste distribution design and storage
- IBC/drum & dry goods transfer/pumping stations & distribution design
Automation and Control:
- Complete electrical design and installation
- Complete Siemens platform SCADA
- Control room
Engineering Services
Briggs of Burton were successful in completing the Front End Engineering Design (FEED) and the subsequent Detailed Design, which included the following deliverables.
- Process Flow Diagrams (PFDs)
- Basis of Design
- User Requirement Specification (URS)
- Capacity planning including utility and effluent loading
- Support on emissions modelling during planning
- Overall plant configuration and equipment sizing
- Piping and Instrumentation Diagram (P&IDs)
- 3D Model and 2D layouts including major equipment and piping
- Electrical design and implementation
- Automation control system and software writing
- HAZOP review
- DSEAR/ATEX risk assessment, zone specification & explosion protection document
