Case Studies

Novel Agarose Bead Production Facility







Design and build Novel Agarose Bead Production Facility

Novel Agarose Bead Production Facility

Purolite Life Sciences’ have invested in a multimillion pound production facility in Wales capable of producing 30% of the world’s agarose demand. The state-of-the-art manufacturing facility designed and built by Briggs of Burton will be located at Purolite’s R&D Centre of Excellence in South Wales. It will be capable of producing 100,000L of high flow agarose resin for their Praesto® range of ion-exchange and Protein A affinity resins, designed for the purification of monoclonal antibodies.

Bespoke Production System

Briggs of Burton supported Purolite in scaling up their process that is capable of handling a range of liquids and powders to produce their product range. Process and Tank Farm/Utility Vessel Package including:

  • Wide range of heating and cooling vessels with agitators
  • Several mobile vessels fitted with agitators
  • A number of wash columns

Integration of Utilities:

  • Design and integration of compressed air and nitrogen systems
  • Chiller system and purified water system
  • Segregated effluent system design to storage tanks
  • Bulk chemical and waste distribution design and storage
  • IBC/drum & dry goods transfer/pumping stations & distribution design

Automation and Control:

  • Complete electrical design and installation
  • Complete Siemens platform SCADA
  • Control room

Engineering Services

Briggs of Burton were successful in completing the Front End Engineering Design (FEED) and the subsequent Detailed Design, which included the following deliverables.

  • Process Flow Diagrams (PFDs)
  • Basis of Design
  • User Requirement Specification (URS)
  • Capacity planning including utility and effluent loading
  • Support on emissions modelling during planning
  • Overall plant configuration and equipment sizing
  • Piping and Instrumentation Diagram (P&IDs)
  • 3D Model and 2D layouts including major equipment and piping
  • Electrical design and implementation
  • Automation control system and software writing
  • HAZOP review
  • DSEAR/ATEX risk assessment, zone specification & explosion protection document